Word: aave
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...extra copy of the follistatin-producing gene has shown that blocking myostatin, by increasing follistatin, causes muscles to bulk up fast. What Kaspar and his team found was that the same effect could be achieved simply by injecting genes - ferried aboard a small, non-disease-causing virus known as AAV, or adeno-associated virus - into the muscle. They further discovered that once the gene was delivered into the muscle-cell nucleus, muscles began producing their own constant supply of follistatin, and muscle fibers kept growing. Think of it as the body producing its own muscle-boosting drugs...
...vast majority of other trials, scientists are hard at work developing a new generation of viral vectors. One promising candidate, says Pennsylvania's Wilson, is the AAV (adeno-associated virus), a small, benign human virus that does not seem to cause any disease. "It doesn't elicit the same kind of inflammatory response that the other vectors do," Wilson explains. "It's somehow evolved the way to get around that." The AAV also efficiently insinuates itself into nondividing cells and, in tests with monkeys and mice, has enabled the therapeutic gene engineered into it to express itself for more than...
Wilson expects Phase I trials using AAV to begin later this year, first for the treatment of hemophilia and later for a form of muscular dystrophy, a liver metabolic disease and retinitis pigmentosa, an eye disorder. "It's kind of a new wave," he says...
...Toyota has enlarged its rugged but cramped 4Runner; Lexus is just out with a pricey model (in the $50,000-plus range) that it calls the LX450; and Mercedes is hurrying to complete a $300 million factory in Alabama that will build a muscly growler it calls an aav, or all-activities vehicle, with a vip price tag in the mid-$30,000 range. (Will it have the effortless, raunchy, bad-attitude rumble of this writer's black-with-red pinstripes 1985 Ford F-250 plow truck, noble on its big wheels, with two gas tanks, chrome air horns, jaunty...
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