Word: acetaminophen
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Dates: during 1970-1979
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...other drugs, such as monoamine oxidase inhibitors (antidepressants) or indomethacin (an antiarthritic), can induce severe episodes of hypertension. There has also been a case of kidney failure in a woman who had been taking a PPA preparation for a few weeks along with a few tablets of aspirin and acetaminophen...
...University of Pennsylvania Hospital report that as many as 5% of all instances of kidney failure in the U.S.-some 8,000 new cases a year-may be caused by common over-the-counter and prescription analgesics. The usual culprit: a mixture of aspirin and either phenacetin or acetaminophen, ingredients found in many well-known painkillers as well as the APC (aspirin-phenacetin-caffeine) tablets handed out wholesale by some military and industrial dispensaries...
...medical profession's concern about the use of analgesics has been heightened by the aggressive introduction of aspirin substitutes such as Tylenol and Datril, which contain the drug acetaminophen. Though this drug has the advantage of not causing the stomach irritation associated with aspirin and though it can be taken by the few people sensitive to aspirin, it also has drawbacks: in large doses it can cause liver damage. In addition, since it is not an anti-inflammatory agent, it does not work against the swollen joints characteristic of arthritis...
...page study on analgesics just released by the FDA, a six-member advisory panel confirms that both aspirin and acetaminophen relieve minor aches and reduce fever, but it also issues a sharp warning against extravagant claims. "Adjective-itis," FDA Commissioner Donald Kennedy calls it, and urges new caveats to protect unwary consumers from potential dangers that could accompany overzealous use of analgesics. Among other things, the panel suggests...
...Fixing a standard dose so each tablet of aspirin or acetaminophen for adults contains 325 mg. and those given to children 80 mg. The panel pointed out that such standardized quantities will not only help avoid misuse of the drugs but also assure consumers that they are getting the same quantities of analgesics in different brands...