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...affiliated MassGeneral Institute For Neurodegenerative Disease (MGH-MIND)—identified a novel mechanism of clearing disease-causing mutant huntingtin protein from brain cells by modifying the protein structure for autophagic degradation, a natural degradation process in cells. The introduction of a specific molecular fragment known as an acetyl group into the mutant proteins—a process also known as acetylation—is the key to triggering the destruction of excess huntingtin, according to the findings, which were published in the April 3 issue of Cell. “The novelty of our research is that...

Author: By Gordon Y. Liao, CRIMSON STAFF WRITER | Title: Potential Treatment Method Identified for Huntington's | 4/10/2009 | See Source »

...chemical reactions in the liver. Soon he was delving into a still more important cycle, by which products of sugar and fatty acids are broken down into a group of chemicals including pyruvic acid. This acid is oxidized or "burned" to form a go-between chemical now known as acetyl coenzyme A. Other acids, notably citric, are formed in a series of changes until the cycle begins to repeat itself with the introduction of another molecule of acetyl coenzyme A. In Krebs's citric-acid cycle or "wheel of fortune" reactions, energy is released to body cells...

Author: /time Magazine | Title: Medicine: Co-Workers & Coenzymes | 11/2/1953 | See Source »

...Schenley Laboratories' trade name for 4-acetyl-aminobenzaldehyde-thiosemicarbazone...

Author: /time Magazine | Title: Medicine: War Booty | 11/21/1949 | See Source »

...nerve gas" like acetyl choline, one drop of which in liquid form will, if placed on a skin abrasion, quickly induce unconsciousness, followed later by no ill effects. Swiss sources last week said the Germans had experimented with such a gas - with a faint geranium odor - against which ordinary filter masks are useless...

Author: /time Magazine | Title: TACTICS: Nerve Gas? | 5/20/1940 | See Source »

...cheap money. Despite its relative obscurity, success of the issue was assured because of Dow's impeccable position in its field. Dow Chemical Co. is not widely known to the public because it does not sell directly to the consumer. For example, Dow sells aspirin (acetyl salicylic acid) by the barrel or sack, lets someone else put an advertised name on the drugstore package. It sticks to the primary manufacture of essential ingredients, lets others make the trade names...

Author: /time Magazine | Title: Business & Finance: Brine Business | 12/28/1936 | See Source »

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