Word: acetyl
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Dates: during 2000-2009
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...affiliated MassGeneral Institute For Neurodegenerative Disease (MGH-MIND)—identified a novel mechanism of clearing disease-causing mutant huntingtin protein from brain cells by modifying the protein structure for autophagic degradation, a natural degradation process in cells. The introduction of a specific molecular fragment known as an acetyl group into the mutant proteins—a process also known as acetylation—is the key to triggering the destruction of excess huntingtin, according to the findings, which were published in the April 3 issue of Cell. “The novelty of our research is that...