Word: acetylationã
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Dates: during 2009-2009
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...novel mechanism of clearing disease-causing mutant huntingtin protein from brain cells by modifying the protein structure for autophagic degradation, a natural degradation process in cells. The introduction of a specific molecular fragment known as an acetyl group into the mutant proteins—a process also known as acetylation??€”is the key to triggering the destruction of excess huntingtin, according to the findings, which were published in the April 3 issue of Cell. “The novelty of our research is that it links acetylation to degradation, which hasn’t been shown before...
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