Word: acidic
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Dates: during 1950-1959
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...analogue (close chemical kin) to fill the metabolite's place but yield no nourishment. First to use antimetabolites this way was Dr. Sidney Farber of Boston Children's Hospital and the Children's Cancer Research Foundation. Knowing that leukemic cells are avid for the vitamin folic acid, he began in 1947 to treat child victims of acute leukemia with analogues of folic acid. Lederle Laboratories sent Dr. Farber two, aminopterin and amethopterin. which soon brought about improvement in most of the children. But after weeks or months, their disease became resistant...
DALLAS MORNING NEWS : While Mrs. Luce's acid remark about the Senator after her confirmation by his colleagues was far from tactful, she was a much abused lady. Her reaction, if not diplomatic, was democratic. The sound in the offing is doubtless her fellow Americans crying "Hear, hear...
...fast detection method was reported to a meeting of the International Academy of Pathology in Boston. Developed at Washington's Walter Reed Army Hospital, by Captain Leroy H. Dart Jr. and Master Sergeant Thomas R. Turner, the new wrinkle rests on facts about the cell's nucleic acids that were unknown in 1943. Biochemists are now sure that deoxyribonucleic acid (DNA) generally increases in human cancer cells; they suspect that ribonucleic acid (RNA) also rises. If the nucleic acid can be spotted under a microscope, it should be a tipoff to cancer...
...detect DNA and RNA, the Army team used acridine orange, a fluorochrome dye that easily unites with the nucleic acids and shines brightly under ultraviolet light. Result: the higher the cell's nucleic acid content, the more intense the fluorescence (green to yellow for DNA, red for RNA). After a few hours of training, a skilled cyto-technologist can spot malignant cells by the intensity of fluorescence he sees in his microscope...
...Portman's behavior and frequent drunkenness," said Kim, "have made it impossible to stay." Everyone else's immediate denials only produced exchanges worthy of the acid O'Neill script itself...