Word: acidic
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Dates: during 1990-1999
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...Tagamet] is to shore up the battlements before Zantac," says Susan Coleman, managing partner of NCI Consulting in Princeton, New Jersey. When Zantac 75 wins approval for over-the-counter sales in the U.S., she predicts, "World War III starts." She notes that while other over-the-counter acid blockers had been on the British market for a year before Zantac 75 appeared in January, it took only three months to overwhelm the competition. "Zantac on the market will be a significant competitor," says Robert Kniffin, vice president of Johnson & Johnson's external communications. "We shall see." (As if Zantac...
...antacid products. In touting Tagamet HB, for example, SmithKline has to avoid invidious comparisons with Tums, its antacid moneymaker, while J&J/Merck must tiptoe around any comparisons between Pepcid AC and its antacid, the much advertised Mylanta. Meanwhile, Switzerland's Ciba-Geigy has other worries. Though it has no acid blocker available that could bite into sales of Maalox, its bread-and-butter antacid, its competitors' new drugs almost certainly will...
Though hurt by the onslaught of acid blockers, the lower-priced and faster-acting antacids will almost certainly maintain a respectable market share. Tums, for example, costs less than 3¢ a tablet. That compares with more than 40¢ for a one-a-day Pepcid AC tablet or a Tagamet HB two-tablet dose, although both products currently offer substantial rebates. Still, booming sales of the new acid blockers seem to show that heartburn sufferers are not troubled by sticker shock. At a Duane Reade drugstore in Manhattan, Darlene Jackson, 35, picked up a box of Tagamet HB and noted...
...FEELING ALL TOO FAMILIAR TO MILLIONS OF AMERICANS, AN UNCOMfortable, burning sensation that begins in the chest and neck after a meal. The burning is real, caused by acid being regurgitated into the esophagus from the stomach. It occurs when a muscular valve, which should be tightly closed except when food is swallowed, relaxes or operates inefficiently, allowing stomach contents to back up. In other parts of the world, most people accept it as a fact of life--and tough it out. In the U.S., says Dr. John Walsh, former president of the American Gastroenterological Association (A.G.A.), "only a fraction...
What separates the new over-the-counter medications from the old solutions? Antacids, which consist largely of chemical compounds called bases, neutralize the wayward acid, but as acid continues to migrate upward from the stomach, heartburn can return in only a few hours. Acid blockers like Pepcid and Tagamet, on the other hand, go to the root of the problem by suppressing the production of acid in cells lining the interior of the stomach without interfering with normal digestion. These cells normally produce acid when a form of histamine called H2 "docks" with receptors in the cell walls, much like...