Word: acomplia
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Dates: during 2000-2009
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...probably don't need a scientific study to tell you there's no such thing as a magic weight-loss pill. But a paper published today on BMJ.com shows exactly that: Taking federally approved anti-obesity medications, such as Xenical and Acomplia, leads only to modest weight loss - an extra 6 lbs. to 10 lbs. (2.7 kg to 4.7 kg) a year - and it's not likely to radically trim down bulging waistlines. "People have to understand it's very difficult to lose weight," says lead author Raj Padwal, an assistant professor at the University of Alberta...
...difference to a patient's health. On that level, at least, there's little doubt anti-obesity medications can help. The BMJ (formerly the British Medical Journal) paper, a comprehensive review of 30 controlled trials on anti-obesity drugs, showed unambiguously that orlistat (Xenical), sibutramine (Meridia) and rimonabant (Acomplia) all resulted in weight loss - but the drugs' benefits extended beyond that. In one four-year trial, orlistat reduced the incidence of type 2 diabetes by almost a third; orlistat and rimonabant both cut patients' blood pressure; all three drugs lowered certain kinds of cholesterol. Not much data exists...
...first drug that manipulates the endocannabinoid system, a network of cells in the brain, the liver and fat tissue that regulates hunger by linking appetite to the body's reward and satisfaction system. Rimonabant reduces food cravings by deactivating the cannabinoid receptors. The drug, to be marketed as Acomplia, is being reviewed by the FDA and will be targeted at those who not only carry excess weight but also harbor unhealthy signs of metabolic disorders such as diabetes and hypertension. In half a dozen clinical trials, the compound helped 6,000 patients lose up to 10% of their body weight...
...unapproved drug Acomplia made headlines as a potential treatment for obesity, smoking and maybe cholesterol and drug addiction as well...
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