Word: acth
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Dates: during 1960-1969
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...Prizewinners Sir Frederick Banting and Dr. J.J.R. MacLeod, and Dr. Charles H. Best) of insulin for the treatment of diabetes, who also won world renown for his study of hormones, which regulate the body's metabolic functions, becoming one of the pioneers in the isolation of wonder-working ACTH and cortisone; following a cerebral hemorrhage; in London...
Died. Dr. Philip Showalter Hench, 69, longtime (31 years) chief rheumatologist at the Mayo Clinic, who in the late 1940s first used the wonder hormones cortisone and ACTH, administering them to rheumatoid arthritics with such spectacular results (one woman left her hospital bed to go on a shopping spree) that he won the 1950 Nobel Prize for medicine, sharing it with two biochemists who had isolated the hormones; of pneumonia and diabetic coma; in Ocho Rios, Jamaica...
Because burns are among the most common disfiguring, crippling and fatal accidents, physicians and surgeons have tried almost every imaginable therapy. In the 100 years since Lister discovered asepsis, practitioners have hopefully tried phenol, boric acid, picric acid, iodoform, tannic acid, sulfa drugs and ACTH, only to wind up, after a few years, disappointed in all of them. Now another new and seemingly miraculous treatment has been discovered, and once again doctors are hopeful-this time with better reason...
...action: it not only eases pain but, by lowering the temperature of inflamed joints and muscles, actually helps to check the disease process itself. It has a similar double action in gout. Aspirin's supremacy as an antirheumatic was threatened for a while after the hormones cortisone and ACTH appeared in 1949, but it is once again "the drug of choice," except in special cases where doctors find the risks of the hor mones' side effects are justified...
...difficulties of synthesizing the hormone promise to be immense; HGH, which contains 256 amino acids, is far more complex than ACTH. But Dr. Li is learning more about it with every experiment. Most recently, he injected HGH into a female monkey, causing her to give milk, even though she had not been pregnant. Now Dr. Li is convinced that the hormone does double duty, controlling not only human growth but almost certainly lactation as well...