Word: acth
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...Doctors have recognized from the beginning that in giving patients such potent new hormones as ACTH and cortisone they are playing with fire. Now that the hormones are becoming available to doctors everywhere, the dangers of use without careful controls are increasing. Last week, in the Journal of the American Medical Association, three doctors of Manhattan's Mount Sinai Hospital warned that the hormones might cause hardening of the arteries...
...University research fellow is working with ACTH, the miracle pituitary hormone used to treat arthritis. Martin G. Ettlinger research fellow in Chemistry, said yesterday that his work may be a first step in producing ACTH at a far lower cost than its present $100-a-gram price...
Ettlinger is trying to isolate the ACTH hormone in its pure form. "If this research is successful," he said, "it may lead to the production of a synthetic ACTH which will be available to many more persons than the present product which is extracted from the pituitary glands of hogs...
...reaction. The first phase is shock, in which body temperature and blood pressure fall, along with blood salt and blood sugar. The shock phase may last from a few minutes to 24 hours. Even before it ends, the system begins to mobilize for counter-shock: the pituitary sends more ACTH flooding to the adrenals, where it boosts the output of adrenal hormones. Blood pressure, blood salt and blood sugar increase and the temperature often rises...
...Finger Exercises." Long before Hench and Kendall showed the near-miraculous power of ACTH and cortisone to reverse the course of rheumatoid arthritis (TIME, May 2, 1949), Dr. Selye had outlined the theory into which their facts fitted so neatly. He has become the world's outstanding expert on the endocrine glands-though many dispute some aspects of his theories and some question his methods...