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...stopped the synthesis of all RNA by treating the cells with the specific antibiotic Actinomycin D, which is, incidentally, used to stop the growth of cancer cells. From then on, all protein synthesis depended on pre-existing messengers. He detected new protein molecules by exposing the cells to radioactive amino acids, which are incorporated into any protein the cell synthesizes. Kafatos has made thin sections of the cell and covered them with a thin photographic film. The radioactivity behaves like light and activated the film. His process is called autoradiography. He could then develop the film, count the activated silver...

Author: By Jeffrey D. Blum, | Title: RNA Quest May Unlock Cell's Street | 5/24/1968 | See Source »

...done by Norman's project. In the past, problems have arisen because the hemophiliac dog rejected the new spleen. Rejection occurs when an animal refuses to accept living tissue from another body. In Ellie's case, doctors avoided the threat of rejection with a combination of immunosuppressors: cortisone, actinomycin C, imuran, and antilymphocyte serum...

Author: NO WRITER ATTRIBUTED | Title: Boston Doctors May Have Cure For Hemophilia | 2/9/1968 | See Source »

...chemicals in advance to suppress the body's tendency to reject a graft from anyone other than an identical twin. For this job the Brigham doctors had decided to rely on drugs, and they used a battery of the most potent available: azathioprine (a new immunity suppressor), actinomycin C (an antibiotic used against some cancers), a cortisone-type hormone, heart stimulants, diuretics and even bicarbonate of soda. Time and again, the transplanted kidney began to fail as his body tried to get rid of this "foreign tissue." But each time the drugs...

Author: /time Magazine | Title: Surgery: A Man of Another Kidney | 8/9/1963 | See Source »

...treatment. Reporting at the Cancer Society seminar, Dr. Sidney Farber of Children's Hospital in Boston said that radiotherapy and surgery had previously been effective in 40% of cases, but in the other 60% death usually resulted because the malignancy spread to the lungs. Now an antibiotic (Actinomycin D) has been brought into the battle and, combined with surgery and radiotherapy, the drug has raised the apparent survival rate...

Author: /time Magazine | Title: Cancer: Statistics of Survival | 4/19/1963 | See Source »

...Microbiologist Selman Waksman announced that German scientists have taken the sting from his drug, actinomycin, turned it into a potential weapon against: 1. Polio...

Author: /time Magazine | Title: NATIONAL AFFAIRS,INTERNATIONAL & FOREIGN,SQUALLS IN THE MEDITERRANEAN,OBIT,OTHER EVENTS,SJPEli it OUf: (THIS TEST COVERS THE PERIOD FROM LATE JUNE THROUGH MID-OCTOBER 1953) | 10/26/1953 | See Source »

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