Word: actinomycin
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Dates: during 1960-1969
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...stopped the synthesis of all RNA by treating the cells with the specific antibiotic Actinomycin D, which is, incidentally, used to stop the growth of cancer cells. From then on, all protein synthesis depended on pre-existing messengers. He detected new protein molecules by exposing the cells to radioactive amino acids, which are incorporated into any protein the cell synthesizes. Kafatos has made thin sections of the cell and covered them with a thin photographic film. The radioactivity behaves like light and activated the film. His process is called autoradiography. He could then develop the film, count the activated silver...
...done by Norman's project. In the past, problems have arisen because the hemophiliac dog rejected the new spleen. Rejection occurs when an animal refuses to accept living tissue from another body. In Ellie's case, doctors avoided the threat of rejection with a combination of immunosuppressors: cortisone, actinomycin C, imuran, and antilymphocyte serum...
...chemicals in advance to suppress the body's tendency to reject a graft from anyone other than an identical twin. For this job the Brigham doctors had decided to rely on drugs, and they used a battery of the most potent available: azathioprine (a new immunity suppressor), actinomycin C (an antibiotic used against some cancers), a cortisone-type hormone, heart stimulants, diuretics and even bicarbonate of soda. Time and again, the transplanted kidney began to fail as his body tried to get rid of this "foreign tissue." But each time the drugs...
...treatment. Reporting at the Cancer Society seminar, Dr. Sidney Farber of Children's Hospital in Boston said that radiotherapy and surgery had previously been effective in 40% of cases, but in the other 60% death usually resulted because the malignancy spread to the lungs. Now an antibiotic (Actinomycin D) has been brought into the battle and, combined with surgery and radiotherapy, the drug has raised the apparent survival rate...