Word: adriamycin
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...most common problem involves the heart. Higher rates of atherosclerosis, heart attacks and strokes can stem from early exposure to chemotherapy agents, specifically anthracyclines like Adriamycin. Although powerful against tumors, these drugs can weaken the heart muscle and stiffen the blood vessels, promoting hardening of the arteries at a much earlier age than normal...
...Edwards' original cancer was diagnosed in the fall of 2004. The specifics of her treatment were not made public, but doctors say it's likely that, in addition to surgery and radiation, she's already received three of the most commonly used drugs - Adriamycin, Cytoxan and either Taxol or Taxotere. This potent regimen knocks out tumor cells and causes the familiar side effects of nausea and hair loss. If her original tumor was estrogen-sensitive - meaning growing in response to the hormone - then she is almost certainly taking an estrogen-blocking drug such as Tamoxifen. (See TIME's photo-essay...
Anton Hopfinger, a chemist at the Chicago campus of the University of Illinois, is using computer graphics to identify the site where adriamycin, a chemotherapy drug, binds to cancer cells. "Molecular graphics has been a real boon to the study of large molecules and proteins," he says. "You can think of it as the equivalent of landing an airplane on an aircraft carrier, except in this case you're sitting on the drug molecule and landing on the DNA molecule. If you didn't have graphics, it would be like being blind and still trying to land on the aircraft...
Last week, after winning a U.S. Public Health Service award for co-authoring a paper entitled "The Inhibiting of DNA and RNA Synthesis by Dau-norubicin and Adriamycin in 1-1210 Mouse Leukemia," Meriwether moved to a new job at the Thorndike Memorial Laboratory in Boston. "I haven't talked to my new employer," he says. "He may not dig track." A more important question is whether Meriwether digs competing in the 1972 Olympics in Munich. "First things come first," he says. "My family and my work. But whether I do or don't compete...
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