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...what Dr. Rolf Hilgenfeld and his associates in Germany are trying to do. The researchers examined the coronavirus genome and developed a theoretical compound that could act as a protease inhibitor. By searching for compounds with a similar chemical structure, they quickly found an existing cold drug called AG7088, developed but never marketed by the drug company Pfizer, that might similarly interdict the coronavirus? protease?giving researchers a potential weapon against SARS. ?The compound itself will probably not be used for a drug to treat SARS,? said Dr. Hilgenfeld. ?But it is a very good starting point for designing drugs...

Author: /time Magazine | Title: Devising Drugs | 5/19/2003 | See Source »

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