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Beyond that, things get murky. It's not yet clear, for example, when tau enters the picture. Up to now, most thought the tangles form much later than the plaques. But neuroscientist Peter Davies of Albert Einstein College of Medicine thinks this view will be proved wrong. He believes some still unidentified biochemical event precedes the formation of tangles and plaques, perhaps a malfunction in the machinery that puts proteins together. "The question from the therapeutic standpoint," he observes, "is, What's responsible for the symptoms of disease? What's killing the cells? Is it amyloid...

Author: /time Magazine | Title: The New Science of Alzheimer's | 7/17/2000 | See Source »

...April 1955 pathologist Thomas Harvey performed an autopsy at Princeton (N.J.) Hospital on the cadaver of Albert Einstein. After determining that Einstein died of a burst aneurysm in the abdominal aorta, Dr. Harvey veered just a bit from protocol by making a circular incision in the great man's head, removing the 2.7-lb. brain and dissecting it into 240 pieces before taking the 20th century's most important gray matter home in a glass jar filled with formaldehyde...

Author: /time Magazine | Title: Books: Einstein Rides Shotgun | 7/10/2000 | See Source »

...sounds like the stuff of B movies, but when Michael Paterniti tracks Harvey down in New Jersey nearly a half-century later in Driving Mr. Albert (Dial Press; 211 pages; $18.95), it turns out to be closer to tragedy. For years the doctor has claimed to be conducting independent research on the purloined remains, but he has produced no findings, and reputable scientists dismiss him as a jerk. A parade of wives and children have abandoned him, and he hasn't practiced medicine in decades--all because of his zealous dedication to the chunks of brain. Now, at 84, Harvey...

Author: /time Magazine | Title: Books: Einstein Rides Shotgun | 7/10/2000 | See Source »

Then something funny happens. Actually, nothing happens. The two men relate the way perfect strangers sometimes do, by not talking. Paterniti probes here and there, but for the most part he's left to observe that Harvey is indeed quite a riddle. Driving Mr. Albert's provenance as a magazine article--albeit a National Magazine Award-winning one--becomes painfully clear when Paterniti resorts to rehashing a few well-known biographical details about Einstein, musing about the (yawn) magic of the road and relating the minutiae of his girlfriend trouble, all seemingly to stretch his tale to book length. Driving...

Author: /time Magazine | Title: Books: Einstein Rides Shotgun | 7/10/2000 | See Source »

...tribunal. In melodrama, of course, the villains always win; they're the ones who get to strut. Thus Brian Cox, as Goering, has his drollest mass-murderer role since he played Hannibal Lecter in the 1986 Manhunter; and Herbert Knaup (of Run, Lola, Run) is a handsomely conflicted Albert Speer...

Author: /time Magazine | Title: Nuremberg, TNT, Sunday-Monday, 8 p.m. E.T. | 7/10/2000 | See Source »

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