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...before hitting it with the actual vaccine. In Nabel's lab, that whiff consists of a snippet of DNA from HIV's outer coating--not enough to trigger a full immune response but, as his work was the first to show in animals, enough to put the system on alert. In the past this strategy hasn't worked in humans because our immune system, unlike those of other mammals, doesn't respond robustly enough to DNA alone. To amplify DNA's poor signal strength, Nabel's group sends in the "boost"--a crippled common-cold virus packed with a payload...

Author: /time Magazine | Title: Vaccines Stage A Comeback | 1/21/2002 | See Source »

...that can happen is if a bacterial or viral illness gets out of control before the immune system can respond. That's where vaccines come in. "What a vaccine does," says Nabel, "is alert these specialized cells that an incoming agent could be a problem, and allow the immune system to respond more quickly and effectively than if it had never seen the bug before." In effect, he says, "you move up the immunologic-response chain of events so the final, acquired response kicks in faster...

Author: /time Magazine | Title: Vaccines Stage A Comeback | 1/21/2002 | See Source »

...readers, who have so generously sent me messages, letters and books from all over the world. I have therefore decided to put Galley Girl on hiatus until I can dedicate enough time to give you the quality of work you deserve. Before I go, I'd like to alert you to two fascinating new books. Thanks for your support...

Author: /time Magazine | Title: Galley Girl: Farewell (For Now) Editon | 1/18/2002 | See Source »

Lawrence's style, naturally lit and roughly realistic, matches the writing. Lantana sometimes has the air of a routine police procedural, sometimes the quality of a dour film noir. But this movie, so alert to mischance and dreams that don't quite work out as they should, has a good soul, a heart yearning for decency. What's terrific about it is the way it lets us discover those qualities subtly, inferentially...

Author: /time Magazine | Title: Cinema: Three You Should See | 1/14/2002 | See Source »

...ASPIRIN ALERT Most folks who routinely take low-dose aspirin to prevent a second heart attack think nothing of downing additional anti-inflammatories to quell their arthritis pain. Not a good idea. Scientists have discovered that ibuprofen, sold under the brand names Advil and Motrin, may interfere with aspirin's ability to protect the heart. What's left? Tylenol (in low doses) and prescription anti-inflammatories Voltaren and Vioxx don't mess with aspirin...

Author: /time Magazine | Title: Your Health: Dec. 31, 2001 | 12/31/2001 | See Source »

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