Word: alpha
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Dates: during 2000-2009
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Although most of the audience probably did not know the artist, the effect was profound. Silence draped the room of the stupefied crowd. For a moment, the alpha males in the room abandoned their Godfather cloaks. It was invigorating to see a commercial and response of that nature, and I applaud Cingular for its novel step in Super Bowl advertising. In the midst of tube-sock donning Britney Spears, buckets of beer, 200 lbs. muscle machines and salsa, it is vital to have 60 seconds where one can be reminded of what truly matters in life...
...attention. In 1998 Japanese researchers reported on studies conducted on five young patients with early-onset Parkinson's, all of whom carried a recessive gene that appeared to be associated with the disease. Though relatively rare, the parkin gene is much more common than the defective alpha-synuclein gene, and in places like China, with high rates of early-onset Parkinson's, it may play a role in a significant number of cases. Just last October, researchers at Duke University Medical Center went a step further, reporting their discovery of a previously unseen mutation on the parkin gene that appears...
...competition of alpha males, it would be tough to come up with a closer matchup than combative 60 Minutes reporter MIKE WALLACE and the chest-thumping U.S. Marine Corps. Unfortunately for fans of hand-to-hand combat, a battle between the two parties has escalated only to a war of words. Within days of a crash of the military's troubled V-22 Osprey aircraft, Wallace attempted to contact the pilot's widow. "I did what any reporter would do," Wallace said. "I made a polite, sensitive call." The officer's family and the Marines disagree. In a letter...
...secret: an unashamed sense of show biz. Says A.P.'s executive vice president/general manager, W. Clark Bunting: "We're not just a 1500-mm camera talking about the alpha male and the alpha female." Animal Planet combines a sense of humor and emotion with an irreverent brand of extreme naturalism that crosses the WWF (World Wildlife Fund) with the WWF (World Wrestling Federation). There's Ian ("Shark") Gordon, who gets jaw-snappingly close to great whites. There's Jeff Corwin, who, facing angry elephants in Borneo, explains the need to stand still: "What you do privately in your underpants...
Beta secretase, the gene for which was cloned only in 1999, also provides drug designers with a target. Inside nerve cells it competes with a third enzyme known as alpha secretase, whose activity, some think, may help protect the brain against Alzheimer's disease. When alpha makes the first cut in the precursor protein, gamma secretase makes a second cut that produces not beta amyloid but an innocuous protein fragment known as p3. Elan and Pharmacia, based in Peapack, N.J., among others, are actively working to develop beta secretase inhibitors...