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...first place to look for causes and treatments of Parkinson’s disease is in the brains of patients themselves. As the illness worsens, brain tissue becomes clogged with a protein muck that includes a substance called alpha-synuclein. No one knows exactly what alpha-synuclein does, but it’s believed to play a role in the smooth transmission of nerve signals. When the substance clumps, it can’t do the work it was designed to do, leading to neuron damage, loss of the neurotransmitter dopamine, and eventually to the familiar shakiness of such well-known Parkinson...

Author: /time Magazine | Title: Scary Cure | 12/18/2000 | See Source »

...hunt for a Parkinson’s cure got a boost in 1997, when researchers discovered a tiny population of patients who have a mutant gene that codes for alpha-synuclein. This might seem like open-and-shut evidence that the cause of the illness had been found, except that the vast majority of Parkinson’s patients, whose brains also grow gummed up, do not carry the mutation. Still, scientists are convinced that the bad gene is a powerful clue. "There appear to be more clumps in the brains of people with the mutant gene," says Zigmond. "Learning...

Author: /time Magazine | Title: Scary Cure | 12/18/2000 | See Source »

...retrospect, was Ginger Spice's behavior inevitable? Do you think we ought to admit Red China to the United Nations? Did Oswald act alone? Why do you think Nixon didn't burn the tapes? Was Ronald Reagan a moron or a visionary? Do earth tones really signify the Alpha male? Why, exactly? Did Roosevelt know in advance about Pearl Harbor? You think those Sacco and Vanzetti guys got what they deserved? Did John F. Kennedy in the White House take his orders directly from the Pope of Rome? Would you say that Bill Clinton's roadless lands initiative unwisely ignores...

Author: /time Magazine | Title: Vexing Questions for the Holidays | 12/13/2000 | See Source »

Black fraternities are also getting involved. In Maryland the Howard County alumni chapter of Alpha Phi Alpha runs a mentoring program for high school males, helping boost their grades and inspiring them to apply to college. Says program head David Barrett: "So many of our boys are in prison. The ones in school--they're under tremendous pressure from their peers not to excel academically. We want to show them that learning...

Author: /time Magazine | Title: The Male Minority | 12/11/2000 | See Source »

...Black fraternities are also getting involved. In Maryland the Howard County alumni chapter of Alpha Phi Alpha runs a mentoring program for high school males, helping boost their grades and inspiring them to apply to college. Says program head David Barrett: "So many of our boys are in prison. The ones in school - they're under tremendous pressure from their peers not to excel academically. We want to show them that learning...

Author: /time Magazine | Title: The Male Minority | 12/2/2000 | See Source »

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