Word: alterations
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...Paul Reubens, the comedian who had crafted his bizarre alter-ego of Pee-Wee Herman, Burton found a comrade-in-oddness and the perfect start to work with on this all-important first film. With a story centering around Herman's search for his lost bicycle, Adventure led one on a surreal road trip across the U.S. complete with giant concrete dinosaurs, biker gangs and a memorable rendition of the song "Tequila." One of the sleeper hits of 1985, Pee-Wee's Big Adventure established Burton as a "bankable" director...
...continues to grow internationally, the committee will no doubt get busier. Certainly the medical-ethics front will get murkier. "We are only at the tip of the iceberg," says Soderquist. "There will be lots of issues that will come up: suicide pills, genetic engineering. Can they prescribe pills that alter the genes...
...idea of implanting brain stem cells, while not as dramatic as swapping whole brains, also raises intriguing philosophical questions. "Sometimes at seminars when I talk about my work," says Snyder, "somebody will ask me whether the introduction of these stem cells will alter memory." Do the newly generated cells distort or erase old memories? Or will the transplanted stem cells bring with them memories of their upbringing in a Petri dish...
...science provides a quick fix, that is. So far, the record on diet pills has been pretty dismal. Amphetamines, which speeded metabolism and suppressed appetite, looked promising in the 1950s and '60s but turned out to be physically harmful and powerfully addictive. Drugs like fen-phen and Redux, which alter the brain's chemistry, had scary side effects. Newer drugs like orlistat and food substitutes like olestra keep fat from entering the body, but they cause serious bowel discomfort...
...know. Perhaps our grandchildren, or their grandchildren, will know. But I, for one, decline to accept the end of the oceans, for to do so would be to accept the end of humanity. I see signs that we are starting to alter our course--laboriously, yes, barely perceptibly, like a supertanker beginning a slow turn in a heavy sea, but changing direction nevertheless...