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...source of this difference lies in the promoter attached to HoxC8, a hox gene that helps shape the thorax of the body. The promoter is a 200-letter paragraph of DNA, and in the two species it differs by just a handful of letters. The effect is to alter the expression of the HoxC8 gene in the development of the chicken embryo. This means the chicken makes thoracic vertebrae in a different part of the body than the mouse. In the python, HoxC8 is expressed right from the head and goes on being expressed for most of the body...

Author: /time Magazine | Title: What Makes You Who You Are | 6/2/2003 | See Source »

...name is Joyce). All you need do is switch the same ones on and off in different patterns. Suddenly, here is a mechanism for creating large and small evolutionary changes from small genetic differences. Merely by adjusting the sequence of a promoter or adding a new one, you could alter the expression of a gene...

Author: /time Magazine | Title: What Makes You Who You Are | 6/2/2003 | See Source »

...does this new view of genes alter our understanding of human nature? Take a look at four examples...

Author: /time Magazine | Title: What Makes You Who You Are | 6/2/2003 | See Source »

...Turner Prize nominations have become the British art scene's annual rite of ridicule. Last week's announcement that the shortlist included ceramist Grayson Perry, whose works depict scenes from the life of his alter ego, a woman named Claire, gave the tabloids more than their usual grist for outrage at the state of contemporary art. pornographic potter gunning for ?20,000, screeched the Daily Mail. But the tabs' time might be better spent exploring the cozy relationship between the Turner Prize judges and the nominees. Andrew Wilson, who short-listed Perry, was paid to pen a catalog essay...

Author: /time Magazine | Title: A Question Of Judgment | 6/1/2003 | See Source »

...unfortunate, or romantic, they are not fools. They now realize that independence will not suddenly become an option today. Instead, they, along with the Indians and Pakistanis, should seek to effectively end the partition of Kashmir without having to change the geopolitical status quo. One way is to alter the character of a border, rather than eliminate it, as Europe has so successfully done. India is ready for a "soft" Line of Control?featuring checkpoints through which Kashmiris can easily pass to meet their relatives on the other side?once it is confident that Pakistan has bottled up the militants...

Author: /time Magazine | Title: Backed into a Reasonable Corner | 5/12/2003 | See Source »

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