Word: altered
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That mechanism was still a mystery in 1891, when Dr. William Coley, an American surgeon, first observed the beneficial effects of certain infections on patients with cancer. Coley began injecting patients with mixed bacterial toxins to induce responses that might alter the course of the malignancy, and without fully understanding what he was doing, succeeded. In 1893, he injected his toxin into a 16-year-old boy with inoperable cancer and was rewarded with a demonstrable success: the tumor shrank and, over a period of a few months, disappeared. He treated some 250 other patients who also improved and survived...
...Perhaps your inaction was due to the specific heading they included on their letters; perhaps it was not. My only intent in not being specific is simply to circumvent the red-tape that has obviously ensnarled your bureaucratic machinery, and communicate directly with someone who possesses the power to alter your basketball program. Your basketball program, in case you gentlemen have not heard, is not doing as well as was expected. In fact, it it hurting a lot of people, not the least of whom are the players themselves...
Gregory is remarkable for sheer theatricality. His special gift is to alter the ratio of expectation between an audience and a work. In Endgame, he has taken an austere doomsday play and injected it with manic laughing...
Whether or not the small coterie of artists will radically alter America's concept of the automobile, they have at least made a small dent in modern American...
...problems of moral choice? Would it be possible to group courses together which attempt to provide a basic understanding of painting, literature, music and other forms of art? This is more than merely a matter of classification. The process of identifying groups of courses along these lines will alter the way in which the institution informs its students about its aims while encouraging greater effort to insure that the curriculum responds to important educational objectives...