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...Massachusetts General tested another anesthetic, isoflurane, on a culture of human brain cells. (Isoflurane had already been shown to cause cognitive impairment in rats.) He saw a vicious cycle of apoptosis and the accumulation of beta-amyloid protein - the sticky plaques that build up in Alzheimer's patients' brains - among the cells. But in this case, it may have been an excess of calcium that led to cell death. Xie and his colleagues have since found that the Alzheimer's drug memantine, which works by reducing calcium levels inside cells, can slow the rate of isoflurane-induced cell death. "That...
...Several large population studies into anesthetics are now under way among both young children and elderly patients. Wilder anticipates that "we are about five years away from getting to the bottom of this." If anesthetics do prove to be neurotoxic, it could be a regulatory and ethical nightmare to decide how best to continue using them. For Xie's part, he thinks researchers must come up with alternative drugs for vulnerable patients if such a scenario unfolds. "Science doesn't always tell us what we want to hear. If certain drugs are dangerous to use, then we should...
...there a mood, though, of bipartisanship among Republicans? If there is an honest attempt to involve them, but there hasn't been. When Nancy Pelosi and Harry Reid make it clear that their attitude is, 'Look, we won the election and, whether these guys participate or not, we don't care,' they made that very clear. The Republicans have offered very specific ideas, such things as medical malpractice reform; they've talked about portability where you could buy insurance across state lines, they've talked about making sure there were incentives for people to go into general medical practice. There...
...become conventional wisdom even among the U.S. and its NATO allies that stability in Afghanistan will ultimately depend on a political settlement that somehow involves most of those currently fighting under the Taliban rubric. So just as the U.S. chose to avoid the very election it had forced Karzai to accept and turned instead to brokering a backroom deal that would dilute the incumbent's authority, any political solution in Afghanistan will have be negotiated on the basis of the real distribution of power, rather than votes cast in an election staged in the heat of a civil...
...previous position that the peace-and-order climate in the areas reconquered by the military should not be undermined by speedy resettlement. Sri Lanka has an estimated 186,000 internally displaced people, refugees from the war with the Tigers. He warned that there might still be thousands of Tigers among them and that they needed to be weeded out. He said nothing about his alleged presidential ambitions, only that "the people who really know the victory are those who went to battle...