Word: amphotericin
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...mild and self-limiting, there's no consensus on how aggressively it should be treated. However, once serious symptoms appear -- including skin rashes, labored breathing and achy joints -- treatment must be prompt. Unfortunately, all four antifungal drugs in use are disagreeable and often toxic. The worst, victims agree, is amphotericin B, known as "Ampho the Terrible" to those who have to have it injected into the base of their skull for meningitis. The side effects include nausea, fever and kidney damage. In severe cases, where the fungus has permanently damaged lung or bone tissue, surgical repair may be needed. Since...
...fever in 1988. It spread into his brain membranes, causing a stroke. Today, although his paralysis is gone, he is still fighting the disease. Every Friday, Sanders has to go to his doctor's office for a cisternal tap, in which spinal fluid is removed, tested and mixed with amphotericin B for reinjection. There is no end in sight to the painful procedure...
...little of one drug or the other. But many physicians have gone on prescribing them. The most noted example was Upjohn's Panalba (tetracycline with novobiocin), which is now off the market. Soon to follow, if FDA has its way: Squibb's Mysteclin-F (tetracycline with amphotericin B) and Roerig's Signemycin line (tetracycline with troleandeomycin...
...farther than the windpipe and lungs, it may touch off what seems like a bad cold. More severe cases are often mistaken for bronchitis and tuberculosis. But the deadliest form of the disease is inflammation of the brain covering. Cryptococcal meningitis was always fatal until the antifungal drug, amphotericin B, came into use six years ago. Now the death rate is down to about 30% of meningitis victims. But nobody knows exactly how many cases of CN lung disease there are because the vast majority are not diagnosed correctly. New York City records about 20 cases of CN meningitis each...
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