Word: amprenavir
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...this, he took a data set provided by Virco Group—a Belgium-based biotech company—containing both sequences of the protease genome and measurements of the amount of amprenavir necessary to inhibit replication of HIV by 50 percent for 2,747 patients...
...analysis identified specific patterns of mutations that are associated with resistance to amprenavir...
...Patients with these patterns should thus be taking drugs other than amprenavir, and possibly, drugs not in the protease inhibitor class—rather, nucleoside or non-nucleoside reverse transcriptase inhibitors or the new class of drugs called fusion inhibitors,” said DiRienzo...
...says Brum, Vertex had identified a likely anti-AIDS drug candidate--code-named VX-478--and signed an $42 million agreement with Glaxo-Wellcome to market and develop the compound under the brand name Amprenavir. Clinical trials began in February, 1995, and approval from the Food and Drug Administration (FDA) is expected...
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