Word: amyloid
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Dates: during 2000-2009
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...detection 30% by combining various cognitive tests with positron-emission tomography (PET). PET is an imaging technique that shows the brain's metabolism at work. Preliminary research suggests that it may also be possible for physicians to detect certain telltale signs of Alzheimer's disease--the so-called amyloid and tau proteins--in the spinal fluid...
...advanced for treatment by the time they are detected, but researchers at Duke University are working on a blood test that could detect the disease in its earliest stages, when the cancer may still be treatable. Their aim is to detect traces of a protein, called serum amyloid A, that is elevated in cancer patients but not in healthy people...
ALZHEIMER'S HOPE? Researchers have discovered a substance that appears to prevent the formation of amyloid plaques, which are implicated in such diseases as Alzheimer's, amyloidosis and Type 2 diabetes. Doctors hope to start a clinical trial within weeks using the experimental drug CPHPC on Alzheimer's patients...
...reasons to remain cautious. For one thing, it may turn out that both these secretases play vital roles in other aspects of cellular metabolism, so that interfering with them will come at the price of serious side effects. For another, it is still far from proven that beta amyloid is as central to Alzheimer's disease as, say, cholesterol is to heart disease. Says molecular neurologist Dr. Peter St. George-Hyslop of the University of Toronto: "We have a theory and experimental data that support that theory, but we won't know the theory is right until we have...
...used to think plaques were like bits of concrete scattered throughout the brain," says Bristol-Myers' Molinoff. "But there's now intriguing evidence that suggests you can get plaque regression." Some of the most striking evidence comes from studies of a vaccine against beta amyloid that Schenk and his co-workers at Elan have developed. In 1999 they administered their vaccine to mice whose brains were filled with plaques. A short time later, the plaques shrank. Currently the Elan vaccine, like the Bristol-Myers' secretase inhibitor, is in early-phase clinical trials, in which the primary objective is to test...