Word: amyloid
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...study, scientists found that elderly lab rats fed curcumin experienced a reduction in the beta-amyloid proteins found in the brains of Alzheimer's victims. When researchers tested curcumin on human beta-amyloid proteins in a test tube, the chemical blocked the proteins from forming destructive plaques?meaning that curcumin could be useful for treating Alzheimer's, and more importantly, for preventing it. Dr. Greg Cole, the lead researcher, hopes that curcumin could be for Alzheimer's what aspirin has become for heart disease: a simple, safe and affordable preventative. New Delhi-based restaurant consultant J. Inder Singh Kalra...
...detection 30% by combining various cognitive tests with positron-emission tomography (PET). PET is an imaging technique that shows the brain's metabolism at work. Preliminary research suggests that it may also be possible for physicians to detect certain telltale signs of Alzheimer's disease--the so-called amyloid and tau proteins--in the spinal fluid...
...advanced for treatment by the time they are detected, but researchers at Duke University are working on a blood test that could detect the disease in its earliest stages, when the cancer may still be treatable. Their aim is to detect traces of a protein, called serum amyloid A, that is elevated in cancer patients but not in healthy people...
ALZHEIMER'S HOPE? Researchers have discovered a substance that appears to prevent the formation of amyloid plaques, which are implicated in such diseases as Alzheimer's, amyloidosis and Type 2 diabetes. Doctors hope to start a clinical trial within weeks using the experimental drug CPHPC on Alzheimer's patients...
...used to think plaques were like bits of concrete scattered throughout the brain," says Bristol-Myers' Molinoff. "But there's now intriguing evidence that suggests you can get plaque regression." Some of the most striking evidence comes from studies of a vaccine against beta amyloid that Schenk and his co-workers at Elan have developed. In 1999 they administered their vaccine to mice whose brains were filled with plaques. A short time later, the plaques shrank. Currently the Elan vaccine, like the Bristol-Myers' secretase inhibitor, is in early-phase clinical trials, in which the primary objective is to test...