Word: anderson
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Clearly, gene therapy is not yet a panacea. Anderson concedes that except for reports of individual patients being helped, "there is still no conclusive evidence that a gene-therapy protocol has been successful in the treatment of a human disease...
...French Anderson, ever pushing the envelope, last September asked the National Institutes of Health to begin considering gene therapy in the womb for fetuses found to be afflicted with a hemoglobin deficiency that would kill them before birth and for fetuses with ADA deficiency, the "bubble boy" disorder he treated in his pioneering 1990 trial...
...critics of gene therapy dismayed by what seems to be the slow pace of progress, Anderson urges patience. "People don't understand that the development of an ordinary drug from time of concept to product is 10 years," he says. "We're talking about a revolutionary approach to therapy, and we're only eight years into...
Ashi's deteriorating condition made her eligible for a landmark experiment proposed by researchers at the National Institutes of Health. In September 1990 a team led by Drs. W. French Anderson and R. Michael Blaese extracted T cells from Ashi and exposed them to mouse leukemia viruses into which human ADA genes had been spliced. The viruses, which the researchers had rendered harmless by removing all their genes, invaded the T cells and burrowed into their DNA, carrying the ADA gene with them. Finally, a billion or so of Ashi's T cells, many of them now outfitted with...
...Anderson concedes that the historic gene therapy practiced on Ashi did not produce a cure, because the T cells made by her bone marrow still lack their own functional ADA gene. "Nevertheless," he insists, "Ashi does provide the proof of principle that if you put a correct gene into enough cells in a patient, you will correct the disease...