Word: anderson
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...problem is that the altered viruses do not always seek out the target cells and sometimes insert themselves in the wrong place in the cellular DNA. Then too, once in place, the new genes sometimes fail to express themselves. "There are still a few walls to get over," Anderson concedes. He points out that in the initial trial, viruses used for cystic fibrosis, for example, produced an inflammatory response: "So the trials were halted, and another generation of viral vectors was developed. Now we're going to restart the clinical trials with these new-generation vectors," which he thinks will...
...bone-marrow stem cells, from which all of the blood's white cells are descended. Even when the rare stem cells are found, inserting genes into them is difficult because they divide infrequently, and the vectors used in gene therapy insert genes only into cells that are dividing. Had Anderson's group been able to use stem cells in the landmark therapy with little Ashanthi DeSilva, for example, follow-up treatments would not have been necessary. Endowed with the normal gene, the marrow stem cells would have produced a continuing supply of new white blood cells carrying that gene...
Such trials on human patients are vital, Anderson believes, "because you can't just work everything out in test tubes and animal models." He pleads for public understanding and patience as researchers refine their gene-therapy techniques. "People don't understand that the development of an ordinary drug, from time of concept to product, is 10 years," he says. "What we're talking about is a revolutionary new approach to therapy, and we're only five years into...
Here we have our Literary City, birthplace and/or alma mater to Willa Cather, Hemingway, Sherwood Anderson, Dreiser, B. Traven, Algren, Bellow. Who gets to hang the tag on it? Carl Sandburg...
...soft John Tesh, formerly of Entertainment Tonight, a far cry from the prickly Bryant Gumbel and downer sidebars on orphans aired during the Korean Games in 1988. It is hard to forget that Tesh's expertise runs more to the marriage of rocker Tommy Lee and Baywatch's Pamela Anderson than to hard news when he uses "histrionics" to mean history...