Word: androgenous
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...paper "Intersex and the Olympic Games," Rob Ritchie, a urological surgeon at Oxford University, notes that in the 1996 Summer Olympics in Atlanta - the last Games in which all female athletes were subjected to gender testing - eight female athletes were found to be genetically male. Seven of them had androgen-insensitivity syndrome (AIS), a condition in which a genetic male is resistant to androgens, the male sex hormones that include testosterone. In such cases, the testes never descend from the abdomen and the genitalia may resemble female genitalia. (See pictures of Olympic highs and lows...
Ritchie notes that female athletes who in the past have been suspected of being men may have suffered from Androgen Insensitivity Syndrome (AIS), a condition in which a person who is genetically male - that is, their 23rd chromosome pair is XY - is resistant to androgens, the male sex hormones that include testosterone. As a result, the testes present in that person's abdomen never descend, and neither they nor their parents ever realize they are actually boys. Those with complete AIS will have a totally female body on the outside, but will lack ovaries and a uterus. Others may demonstrate...
...This really addresses an unmet medical need for fracture prevention in men receiving androgen-deprivation therapy for prostate cancer," says Dr. Matthew Smith, director of genitourinary medical oncology at Massachusetts General Hospital and the lead author of the HALT paper. "Given that we have such little data on fracture prevention in men, these findings are important...
...Researchers in Sawyers' lab began with a chemical that showed promise in attaching to the androgen receptor on cancer cells. Then the scientists, like composers writing variations on a theme, synthesized nearly 200 versions of the drug and screened each one on prostate-cancer cells that had been engineered to be drug-resistant. In the end, two molecules - RD162 and MDV3100 - fit the experimental criteria, binding to the receptor site without stimulating cancer-cell growth. Both chemical compounds were then tested in mice. "They caused the tumors to shrink significantly," says Sawyers...
...Unlike typical antiandrogen cancer drugs, the new compounds appeared to work by more effectively blocking the androgen receptors on the cancer-cell surface, even when the total number of receptors on the cells was high, as is the case in resistance. (Read "Vitamins Do Not Prevent Prostate Cancer, Study Finds...