Word: anemia
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Dates: during 1940-1949
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...Physical exhaustion may suddenly bring on mild anxiety neuroses in people with long-standing ailments. For instance, a man with anemia who fought fires all night was too tired to sleep. He was quiet, controlled, somewhat despondent. At a shelter he was given rest, food and drink. Immediately he began to tremble, broke out in a cold sweat, groaned and paced the floor...
Only four doctors have been considered eminent enough to win this privilege: Dr. Bela Schick, inventor of the Schick test for diphtheria immunity (not to be confused with Jacob Schick, inventor of the Schick razor); Nobelman George Hoyt Whipple, co-discoverer of the liver treatment for anemia; Dr. Manfred Sakel, originator of the insulin shock treatment for schizophrenia; Dr. Benjamin Philp Watson, head of Columbia's Sloane Hospital for Women...
Sulfanilamide, the parent drug, was first tried on a wide variety of bacterial infections. At present its use is limited mainly to meningitis, erysipelas, urinary-tract infections. It is easy to take, "well handled by the body and excreted without difficulty," but it brings about two "exceedingly common" complications: anemia and cyanosis (lack of oxygen). On the whole, it is "less effective therapeutically than other related compounds and is being supplanted by them." It is the only sulfonamide compound which can be given rectally with success...
Sulfathiazole is "the most important sulfonamide drug in use at present." It is a powerful weapon against pneumonia, staphylococcic infections and a great range of streptococcic infections. Resultant anemia and cyanosis are "less marked" than with the use of sulfanilamide. But sulfathiazole has other drawbacks: 1) it causes fever, skin rash, inflammation of the eyes more severely than other sulfa drugs; 2) it must be used for a relatively longer period of time, thus increasing danger of complications...
Died. Nicholas ("Collective Security") Titulescu, 57, towering, trigger-witted Rumanian diplomat, picturesque pillar of the League of Nations in its palmy days, six times his country's pro-French, pro-democratic Foreign Minister, leader with Eduard Benes in the late Little Entente; of pernicious anemia resulting from tuberculosis; in exile, in Cannes, France...