Word: angiotonin
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...green, the child has the disease. Hope is that physicians generally will adopt the simple test. ¶Cleveland Clinic researchers headed by Dr. Irvine H. Page (TIME. Oct. 31, 1955) reported a chemical victory that may lead to better understanding and treatment of high blood pressure. They have synthesized angiotonin II, the active form of the hormone angiotonin (discovered by Page in 1939), which sends blood pressure zooming when injected. Hitherto available only in minute amounts laboriously extracted from tons of animal glands, it can now be made in quantity for intensive research...
...hypertensives seem to inherit a tendency to it; even babies sometimes have it. Dr. Page blames excitable nervous systems for a great many cases (evidenced by the fact that anger or fear makes blood pressure jump), and he suspects that another source of the disease is a chemical called angiotonin, released by the kidneys when their blood supply goes wrong...
...pressure and stops hypertensive headaches), remove a diseased kidney (but be sure it is the right one) or cut the nerves that connect the abdominal blood vessels with the nervous system. Dr. Page modestly dismisses as still an unproved experiment his own discovery-a kidney extract injected to counteract angiotonin (TIME, March 3, 1941)-although it has effected some remarkable cures...
...series of ingenious experiments, researchers found renin, an organic chemical manufactured by the kidneys, which raised the blood pressure of animals. They also found an activator in the blood plasma which enabled renin to work. The combination of renin and this activator was dubbed angiotonin. As a working hypothesis, angiotonin was marked as the chemical cause of high pressure. Further experiments showed that normal kidneys probably manufacture an "inhibitor" substance, which destroys or neutralizes surplus angiotonin, keeps the pressure within normal bounds. Two research teams, including Dr. Page's in Indianapolis, recovered from kidney extract inhibitors which lowered...
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