Word: anti-tb
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After a long period of decline, TB incidence has risen dramatically since the 1980s, despite the improvement of sanitary conditions, the development of anti-TB drugs in the 1950s, and the introduction of the World Health Organization’s directly-observed treatment short-course program for more effective treatment. In 1993, the WHO declared TB a global-health emergency, setting ambitious goals which it later conceded could not be met by 2003 or possibly even 2015. That is to say, the consequences from the years of inadequate treatment and low attention to disease control in resource-poor regions have...
...physician noticed that some of those TB patients, many of whom were H.I.V.-positive, were not getting any better, despite being on anti-TB medications. Nothing he provided them seemed to control the tubercle bacillus flourishing in their bodies. Of the 53 who were sickest, 52 died, most within a month of entering the hospital...
...century after the bacillus responsible for the disease was first identified and decades after the first antibiotic treatments, TB continues to survive, even thrive, in ever more aggressive forms. In 2006, 9.2 million more people were diagnosed with the disease, almost exclusively in the developing world, and 1.7 million people died from it. More alarming is a growing subset of TB cases, estimated at half a million, that are resistant to more than one of the handful of anti-TB drugs. While they still make up only 5% of the total annual TB burden, these cases of multidrug-resistant...
...biggest threat, XDR TB, is currently resistant to the most potent classes of first- and second-line anti-TB drugs available - and there is no third line of pharmaceutical defense. While some promising candidates are being tested, even if they prove effective, they will not be available for at least five more years. There is also no easy way to detect drug-resistant strains of TB; current sputum-based screens can take anywhere from two weeks to two months, during which time doctors protectively place infected patients on first-line drugs too weak to battle the aggressive strain effectively rather...
...more than a century after the bacillus responsible for the disease was first identified and decades after the first antibiotic-based treatments appeared, TB continues to thrive. In 2005 the disease was diagnosed in 9.2 million more people, almost exclusively in the developing world, and 1.7 million people died from it. More alarming is a growing subset of TB cases, estimated at half a million, that are resistant to more than one of the handful of anti-TB drugs. While they still make up only 5% of the total annual TB burden, these cases of multidrug-resistant and extensively drug...