Word: anticholesterol
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Physicians advise that the study results do not point to a miracle drug that will provide a risk-free cure for heart disease. For example, gemfibrozil seems to predispose people to develop gallstones. Moreover, doctors recommend that anticholesterol drugs, including lovastatin, which was approved by the Food and Drug Administration in September, should be used only as a last resort...
...search for a new anticholesterol drug began in Japan. Akiro Endo, a scientist with the pharmaceutical firm Sankyo, wondered whether soil molds that kill cholesterol-containing bacteria might have evolved the ability to block cholesterol synthesis. In 1976, after testing 10,000 compounds, Endo found one that inhibited a key enzyme in the cholesterol-manufacturing process. Researchers at Merck soon discovered similar compounds, including lovastatin, but the finds would have remained research oddities without the Nobel-prizewinning work of UTHSCD's Joseph Goldstein and Michael Brown...
...approves a new anticholesterol drug called lovastatin. -- Researchers report that a hormone beefs up the immune system...
...surgery would slow the growth of new blockages in the coronary vessels. ( But the proper treatment has proved elusive. Last week in the Journal of the American Medical Association, Dr. David Blankenhorn of the University of Southern California reported that patients who were treated with a combination of the anticholesterol drug colestipol and the vitamin niacin showed a marked improvement over those who had maintained a low-fat diet alone...
After two years, X rays showed that life-threatening plaque had started to melt away in 16.2% of the treated patients, vs. 2.4% in the control group. The results were so dramatic that some health professionals called for routine anticholesterol drug treatment after bypass surgery. Cardiologist Blankenhorn, who was one of the 162 subjects of the study, demurred: "Drugsalone are not enough. People are still going to have to change to a healthier life-style...