Word: antiestrogen
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...Strauss, 76, is a retired preschool teacher from Chapel Hill, N.C., just down the road from Duke. For five years she has battled breast and liver cancer. Chemotherapy gave her two years in remission. The new breast-cancer treatment tamoxifen provided two more. Another year was gained from another antiestrogen drug. Then doctors ran out of approved medications...
...greatest unknown, from a scientific point of view, is raloxifene's effect on the brain. The drug is known to increase the number of hot flashes, which are usually triggered by the brain's attempts to deal with falling hormone levels. This suggests that raloxifene might act as an antiestrogen in the brain. Recent studies have shown that estrogen may provide some protection against dementia and other types of nerve disorders. Therefore, taking raloxifene for long periods of time could theoretically increase the risk of developing Alzheimer's disease...
Doctors have been treating breast cancer patients with tamoxifen, a drug used in very advanced cases, at an earlier stage of the disease. The theory: many if not most breast cancers are linked with the hormone estrogen. Tamoxifen is an antiestrogen agent that has shown a no table ability to halt the growth of estrogen-connected tumors...
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