Word: antigen
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Dates: during 1970-1979
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...chromosome other than the usual Y. The proof of this aberration came from an immunological experiment; white blood cells from an XX male were mixed -and then reacted-with a test antiserum. That reaction was confirmation of the presence of the so-called H-Y or "male" antigen...
...father's testes. In any case, the test has already been put to important clinical use. At New York Hospital-Cornell Medical Center, for example, a two-year-old child with an enlarged clitoris but a seemingly normal XX chromosome pattern was tested for H-Y antigen. The assay turned out positive, and subsequent surgery revealed the reason: she was a hermaphrodite, with dual sexual organs-an ovary on one side and a combination of ovary and testis on the other. The doctors promptly removed the ovotestis, thereby reducing the danger of cancer and ensuring that she would...
...Bronx Veterans Administration Hospital, both the first woman and first nuclear physicist to win a Lasker prize. Together with the late Dr. Solomon A. Berson, she developed a sophisticated new tool called radioimmunoassay (RIA) for measuring minuscule quantities of pharmacological and biological substances. Using radioactive isotopes as tracers in antigen-antibody reactions, the technique is becoming increasingly important in everything from diagnosing disease to finding poisons in murder victims...
Blumberg, 51, of Philadelphia's Institute for Cancer Research, identified a blood-carried viral particle, "Australia antigen," associated with a debilitating liver disease, hepatitis B. His biomedical detective work, involving an aborigine's blood, not only led to a method of testing potential blood donors for hepatitis but also paved the way for an experimental antihepatitis vaccine...
...multiple mosquito bites in the three months preceding their infection. The insects might well have given them the disease. When the researchers, using newly developed techniques, examined 251 batches of mosquitoes from 15 sites in the state last summer, they found that ten of the groups carried hepatitis antigen-convincing evidence that the insects had also harbored the virus...