Word: antigenically
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Another factor, says Lu-Yao, is the widespread use of the prostate-specific antigen (PSA) screen beginning in the 1990s. The controversial screen measures PSA levels in the blood to determine whether prostate cancer may be present. Since the screen can detect the tiny, early-stage cancers that in years past would have gone unnoticed, the number of patients diagnosed with (and cured of) prostate cancer in the modern era has gone up. Within the over-65 set in her study, Lu-Yao says, more patients were probably diagnosed with early-stage, survivable cancer compared with patients diagnosed from...
...vaccinemakers have already reported problems; the amount of antigen, the active ingredient in vaccine, reaped from each batch is only about 25% to 50% of the norm for seasonal flu vaccine. That means it will take longer to manufacture H1N1/09 vaccine - and since very few people have immunity to this flu strain, people may need two shots, which means annual global capacity would drop to a little more than 400 million doses...
...drug company Medivation, for which Sawyers is a paid consultant, chose MDV3100 to test in a clinical trial. In initial studies, 30 patients who had drug-resistant prostate cancer were given doses of MDV3100. Twenty-two showed a sustained reduction in their blood levels of prostate-specific antigen, or PSA, a protein that is elevated in the presence of prostate cancer; in 13 of those 22, the decline was more than 50%. That Phase 2 trial is ongoing, but the drug has shown enough promise to prompt the Food and Drug Administration to grant Medivation permission for a large-scale...
Science is not shy about ambiguity, never more so than when it comes to medical advice. So here's the latest recommendation on prostate-cancer screening: Men should continue to have both a manual prostate exam and a blood test for prostate-specific antigen (PSA) every year - bearing in mind that neither test may affect your odds of surviving prostate cancer. (Read "Can a Urine Test Detect Deadly Prostate Cancer...
...people receive the diagnosis each year, only skin cancer is more common. But despite its prevalence, the lack of a fail-safe test is a frustration to physicians. Currently, older men at risk of prostate cancer undergo a PSA test, which detects a protein called prostate-specific antigen in the blood. Men who have elevated PSA levels, which may indicate cancer, undergo invasive biopsies but often end up not having the disease at all. Even when the biopsy finds cancer, physicians are usually unable to accurately tell how quickly the cancer will spread...