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...ANTIGEN OVERLOADING. Though there are at least two major types of antibody represented by billions of particles, they can be either confused or exhausted if the invading particles of foreign antigen (antibody-triggering substances) are numerous enough. In the medical equivalent of a massive military diversion, doctors try to overload the immune mechanism temporarily by flooding it with antigen particles. By coincidence, an antigen sufficiently similar to the human type is in some streptococci. So these bacteria, usually rated as harmful, are being mass-produced in a program backed by the National Institute of Allergy and Infectious Diseases. The antigen...

Author: /time Magazine | Title: Surgery: Circumventing Immunity | 3/10/1967 | See Source »

...many immunologists, and last week Manhattan's Dr. Jonathan W. Uhr, 37, won the Newcomb Cleveland Prize of the American Association for the Advancement of Science for advancing man's knowledge of how little he still knows about how virus infections, vaccinations and other antigen-antibody reactions really work...

Author: /time Magazine | Title: Immunology: How Antibody Is Made | 1/8/1965 | See Source »

...useful application in human medicine, but Immunologist Uhr, who is now director of the Irvington House Institute for Rheumatic Fever and Allied Diseases, has already shown that newborn babies react to ΦX in much the same way as guinea pigs. And children's reactions to antigens are immensely important in rheumatic fever, which seems to result from the body's mistaking part of its own heart muscle for an invading bacterial antigen...

Author: /time Magazine | Title: Immunology: How Antibody Is Made | 1/8/1965 | See Source »

Fascinating Mono. In these three cases, it is easy enough to understand how the body can regard the escaping antigen-protein as "new" or "foreign," because it has been sequestered for years, perhaps since the fetal stage. Far more knotty are the questions that arise so often in Dr. Dameshek's practice as a hematologist. No less than 50% of all blood-destroying anemias acquired after infancy, he believes, are the results of autoimmune reactions. He is so confident of this that he abbreviates the disorders to AIHA-autoimmune hemolytic anemias...

Author: /time Magazine | Title: Immunology: How Man Becomes Allergic To Parts of Himself | 5/1/1964 | See Source »

...University of California at Los Angeles. Nearly everybody has antibodies against distemper -surprising, because no human being is known to have caught distemper even from the sickest dog. Dr. Adams reasoned that perhaps the virus is close kin to one that causes human disease, contains the same antigen (antibody-stimulating component). He tried a safety-tested distemper vaccine against respiratory infections in a California institution, and it was a flop. But three years later the institution had a measles epidemic. Among inmates who had had distemper vaccination there was only one-third as much measles as among the others...

Author: /time Magazine | Title: Medicine: Out, Damned Spots! | 6/1/1959 | See Source »

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