Word: antitumor
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...spend money and energy to save, say, the frostweed or the small whorled pogonia? Medical benefits alone, says Thibodeau, could justify the center's efforts: "Well over a quarter of all prescription medicines in the U.S. are based on plant products." He points, for example, to antitumor alkaloids found in the Madagascar periwinkle that are now used in the treatment of childhood leukemia and Hodgkin's disease. "The question," says Thibodeau, "is whether you're willing to bet that there isn't another important drug out there among those 3,000 plants or whether you're willing to hold...
Readers of your report on new antitumor drugs that have been approved for treating breast cancer [PERSONAL TIME: YOUR HEALTH, Sept. 14] were left hanging. They must be asking themselves, "When should I take tamoxifen?" since the panel of experts who ruled on the drug did not endorse the idea that tamoxifen actually "prevents" breast cancer. If you are at proven elevated risk for breast cancer, the answer is, Take tamoxifen at any time. Tamoxifen does not wear out as a preventive after five years; in fact, it "imprints" the breast and protects women for years after they stop taking...
Once malignant cells have spread beyond their original location, however, traditional chemotherapy is usually much less successful at producing a cure. In an attempt to develop a treatment for these more advanced cases, the researchers at Dana-Farber have been experimenting with levels of antitumor agents that are much higher than those normally prescribed. In Lehman's case, the treatment was to last four days, and the amount given during each 24-hour period was supposed to be barely shy of lethal. The physician in charge of figuring out her daily dosage, whose identity has not been released, apparently made...
...companies are already planning to test the antitumor proteins in people. However, clinical trials probably will not begin until 1996 at the earliest. One of the most important issues that scientists will have to address is whether the blocking agents will also prevent the body from forming new blood vessels during the normal course of repairing cuts and other wounds. In addition, researchers must pay particular attention to the proteins' safety for women. The creation of new blood vessels is a regular part of the menstrual cycle and crucial to pregnancy as the fetus grows and develops. So any protein...