Word: antitumor
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Dates: during 1990-1999
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...first two patients -- a 46-year-old man and a 30-year-old woman -- both have terminal-stage melanoma, a form of skin cancer. A few months ago, doctors extracted tumor cells from the patients and inserted into the cells the gene that promotes the production of an antitumor hormone called tumor necrosis ^ factor (TNF). The genetically altered cells were grown in a lab and then injected last week into the thigh of each patient. The hope is that the TNF- primed cells will boost the body's immune system into more vigorous attack against the malignancy...
...second stage of the treatment, two weeks from now, doctors plan to remove white blood cells from the injection sites and nearby lymph nodes, grow them in a lab and transfuse them into the patients. Studies suggest that such cells will have developed a strong antitumor activity...
...piggyback gene into the genetic material of the TILs, which are then injected back into the bloodstream of the melanoma patients. If everything goes as planned, the activated TILs will home in on the tumors like guided missiles, attacking the cancerous cells and at the same time releasing the antitumor factor to help finish them...