Word: app
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...market your politics on the Web? The Democrats started offering free Internet access last month at FreeDem.com but the Republicans may have found the real killer app. At RepublicanShopping.com party faithful can give to the G.O.P. while they shop. A virtual mall that sells everything from rifles to minivans, the site--which has yet to hear from the FEC--has deals with some 400 e-tailers to give an average of 10% of each purchase to the California Republican Party. But not all merchandise is as red-blooded as Charlton Heston. Some of the ways to give seem downright...
...technology that makes the letters easy on the eyes and lets you bookmark and annotate as you go. Barnesandnoble.com is backing the release with 100 free "classic" (read: uncopyrighted) electronic books, including Jane Eyre and Candide. But why read a book on a computer? Paper is still the killer app for reading--you can make book on that...
Almost overnight, it seemed, scientific interest in the genetics of beta amyloid exploded. Researchers had long been aware that early-onset Alzheimer's, while rare, often ran in families. Could it be, they wondered, that the culprit was a mutant version of the APP gene? In 1991 scientists at London's St. Mary's Hospital Medical School screened the DNA of an Alzheimer's family and found what every geneticist in the field had been furiously looking for. The mutant APP gene sat on chromosome 21, and the single change in its DNA sequence occurred in the vicinity...
Sometime later, two more early-onset Alzheimer's genes were found, Presenilin-1 and Presenilin-2. Like APP, these genes were dominant; a child who received just one gene from either parent would inevitably get the disease. One of the most tragic examples involved a 4,000-member Colombian family that had been haunted for generations by Alzheimer's. Yet such cases, researchers were only too well aware, accounted for merely a small fraction of all cases of Alzheimer's disease. Still other genes, they reasoned, must be involved in the great majority of cases--those in which dementia does...
...Roses won the APOE4 argument. Everyone now agrees that this gene is indeed a major risk factor for Alzheimer's disease. But unlike APP and the Presenilins, it is a susceptibility gene. People who carry it do not invariably develop Alzheimer's, but if they do, their brains appear to be more riddled with plaques and tangles than the brains of Alzheimer's patients who carry slightly different versions of the APOE gene. Even more intriguing, APOE4 appears to have a broad impact on the well-being of nerve cells. Among other things, people who carry two copies of APOE4...