Word: aricept
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...According to the pharmaceutical market news service Pharmawire, around $114 billion worth of drugs will go off patent in 2008-12, including lucrative brands such as Eisai's Aricept, which treats Alzheimers, and Pfizer's Lipitor, which lowers cholesterol. Some analysts say patent expirations could lead AstraZeneca and GlaxoSmithKline to lose up to one third of their sales...
...first time--a drug that delays the onset of Alzheimer's in patients with mild cognitive impairment. These are people who have memory problems (slips of the tongue, brief memory lapses) but can still balance a checkbook or prepare a meal. The drug they were given, Pfizer's Aricept, is widely prescribed for patients who already have Alzheimer's. In a trial conducted by researchers at the Mayo Clinic, nearly 800 patients were randomly assigned Aricept, a placebo or vitamin E for three years. In checkups after six, 12 and 18 months, people in the group taking Aricept showed fewer...
Still, lead researcher Dr. Ronald Petersen was encouraged, seeing this as a first step in a process by which scientists "could start to nudge back the onset of the disease by years," possibly even postponing it altogether. Already, many doctors have begun prescribing Aricept for patients at high risk of developing Alzheimer's. If you believe you or a loved one may be a candidate, ask your doctor...
COMBINATION THERAPY A yearlong study of more than 400 Alzheimer's patients showed that two drugs that work differently on the brain's chemistry act well together to help slow down the disease. Patients who were being treated with donepezil (sold as Aricept), an older drug that preserves the neurotransmitter acetylcholine, were also given memantine (Namenda), a new drug approved by the FDA last October that blocks overproduction of a harmful brain chemical called glutamate. The two drugs worked even better in combination than they did alone, providing substantial benefit for patients with moderate to severe Alzheimer's, according...
...meantime, at least five therapies are now being studied around the world for their potential in treating MCI. Among the candidate treatments are vitamin E, anti-inflammatory medications called cox-2 inhibitors and the Alzheimer's drug Aricept. The first results aren't expected for three to four years...