Word: artes
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...second study, Kitahata's team looked at patients who chose to start ART when their CD4 count was 500 or above and compared them with patients who decided to defer treatment until their CD4 counts dropped below 500 cells. (In a normal, healthy adult, CD4 levels range from 600 to 1,200.) In both studies, the patients deferring treatment were more likely to have died by the 2005 end of the study than were their earlier-treated cohorts. HIV-positive patients beginning therapy at CD4 levels between 351 and 500 cells were 69% more likely to be alive...
...very good study that at least suggests strongly that there is a benefit to starting treatment early," says Dr. Anthony Fauci, director of the National Institute on Allergy and Infectious Diseases. But is it enough to change the current guidelines for when HIV-positive patients should start ART? "That is a question of debate now in the scientific and public-health community," he says...
...fact, when the potent ART combination therapy first emerged in the mid-1990s, government health officials recommended that anyone with a CD4 count of 500 cells or lower receive treatment. But in response to growing concerns over HIV's increasing ability to become resistant to the drugs, as well as worries over the drugs' toxicity and patients' inconsistent compliance with their regimen, the guidelines dropped to 200 before eventually settling at 350 cells - much further along in the progression of the disease...
...drugs are not without side effects. Some studies have noted increased risk of certain cancers as well as toxic effects to the brain and other organs over the long term. "The real critical issue that everyone is struggling with is, What about the potential long-term deleterious effects of ART that might override the beneficial effects?" says Fauci...
...silence the critics. His plan for the complex, due to be completed in 2010, calls for a piazza with a fountain and a cafe, designed to draw non-Muslims to the site. The local Muslim elders hope that, once there, visitors will browse in the library, check out the art gallery or spend in the shopping mall, which Böhm envisions as "a modern souk with the quality of the traditional souk." The mosque's prayer hall consists of shells of textured concrete connected by glass panels, to create "ideological and architectural transparency," says Böhm. Far from...