Word: aspirin
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Dates: during 1950-1959
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...clinical tests have consistently shown that addition to aspirin of the particular antacid mixture (i.e., Di-Alminate) used in Bufferin invariably doubles the rate of absorption of aspirin into the blood stream during at least the first thirty minutes after administration...
Bufferin v. Aspirin...
...gastric tolerance is concerned, no published report to date approaches, in our opinion, the caliber of our recent Michigan study. There, tablets of Bufferin, the four leading commercial brands of aspirin, and an inert placebo were administered on different occasions to each of 146 human subjects who presented a history of previous stomach upset from each of the four brands of aspirin. Less than 7% of the subjects reacted to Bufferin. That suggestibility played no role whatever in these studies is evident in that only one of the 146 subjects noted stomach upset from the inert placebo...
Major trouble with previous tests in which some medical researchers thought they detected advantages in buffering the aspirin with antacids, said New York Medical College's Dr. Robert C. Batterman, was that they relied on patients' faulty memories. To rule out this and other sources of error. Dr. Batterman did "double blind" tests: identical-looking tablets, one plain, one buffered, were used with only a code letter for labeling. Neither the patients nor the doctors and nurses knew which was which until after the results were tabulated. The results showed that, buffer or no buffer, there...
Syracuse University's Dr. G. Arnold Cronk ran a similar test, found that from either type of tablet the aspirin gets into the blood at just the same speed, gives equal pain relief equally fast, and the relief lasts the same length of time...