Word: aspirin
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...they appeared seemed to take on a grubby look. Yet the faces of Bill Mauldin's Willie and Joe were as admired and familiar to Americans during World War II as Dwight David Eisenhower's. Irreverent toward rank and cynical about the war-"Just gimme th' aspirin," Willie tells a medic. "I already got a Purple Heart"-Willie and Joe were more than cartoon characters. They were the American...
...step to another sad preoccupation. "Successful suicide," Greene writes, "is often a cry for help that has not been heard in time." With some slight prurience, he describes his schoolboy attempts to cut a vein in his leg, swallow deadly nightshade berries, handfuls of aspirin and, finally, a draft of darkroom hypo-all with no serious results. But when he ran away from school at age 16, his father sent him down to London in 1920 to be psychoanalyzed. The six-month period of analysis, Greene revealingly admits, was the most peacefully pleasant time of his life, along with...
Persuasive Proof. Now a group of British researchers have come up with a partial answer. In a series of papers published recently in the scientific journal Nature, they report that aspirin and its close pharmaceutical relatives tend to halt the production of prostaglandins, hormone-like substances first discovered in the 1930s. Although their exact role is still incompletely understood, prostaglandins occur in semen, menstrual fluid and a wide variety of human tissues. They are known to be involved with the functions of such diverse structures as the heart, bronchial tubes, blood vessels and stomach...
...several years, doctors have suspected a link between aspirin and the prostaglandins, but the findings of the Britons, who conducted their work at London's Institute of Basic Medical Sciences, provide the first persuasive proof. In one series of experiments, Dr. John Vane found that aspirin-like drugs impeded the synthesis of a prostaglandin known to cause fever in cats. In another, Dr. Vane and his colleagues Sergio Ferreira and Salvador Moncada found that aspirin blocked the release of prostaglandins in a dog's spleen that had been removed and kept functioning artificially. In a third, Drs. John...
...important hormones, but also to the development of new and more effective drugs for such ailments as rheumatic fever and arthritis. They may also open up new fields in the study of human fertility. Prostaglandins are presently being used experimentally to induce abortions. The Britons' new discovery of aspirin's effect on their production may lead to the development of aspirin-like drugs to prevent miscarriage...