Word: aspirins
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...glaring difference in results may be explained by the varying sizes of the studies -- and the doses of aspirin consumed. The British doctors took almost twice as much aspirin twice as often as did their American counterparts. That led some researchers to speculate that too much aspirin may counteract the positive effects of lower doses. In addition, says Boston's Hennekens, the larger U.S. trial was far more conclusive statistically. "If you studied 5,000 doctors," he declares, "you'd have to follow them for 20 years to get the same results." Which report is to be believed? Says...
...even begins to measure up to the expectations of the U.S. study, aspirin could become the cardiologist's dream. It is inexpensive, readily available, effective in low dosages and relatively nontoxic for most people. First derived from willow bark and now chemically synthesized, aspirin works by blocking the manufacture of hormone-like chemicals called prostaglandins that are instrumental in the formation of blood clots...
...many in the U.S., where 10 billion aspirin are consumed each year, there are also potentially serious side effects. These complications, including gastrointestinal distress, rectal bleeding and peptic ulcers, have caused researchers to temper their excitement over the implications of the American study and warn individuals not to take aspirin frequently except under a doctor's care. Says William Kannel, chief of preventive medicine at Boston University and a former director of the Framingham Study, a long-term heart-research program: "The most rational use would be in high-risk people, rather than having everyone gobble aspirin." Claude Lenfant, director...
Nonetheless, many researchers guess that the proper use of aspirin could save 100,000 lives a year in the U.S. Heart disease, it seems, may be finally giving way to treatments both old and new, including both aspirin and artificial clot-dissolving drugs, and a growing concern about exercise, diet and smoking. But just how effective the familiar pills from the family medicine chest are in preventing heart attacks remains something of a mystery...
Researchers try to determine if an aspirin a day will keep the heart doctor away. -- Should college students take AIDS tests...