Word: aster
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...study, Aster and his co-workers have discovered a common mutation in a gene called NOTCH1 in 55 to 60 percent of all T-cell acute lymphocytic leukemia patients...
...That’s a substantially higher number than any other mutation found in the cancer,” said Aster...
According to Aster, normal NOTCH1 gene activity is essential for T-cells, which defend the body against disease, to mature. The NOTCH1 gene is mediated by a critical molecule called gamma secretase...
According to Aster, stopping the effects of the gamma secretase would bypass NOTCH1’s abnormal activity, thus stopping the cancer from progressing...
...Gamma secretase inhibitors are not yet on the market,” said Aster. “However, several colleagues of mine informed me that gamma secretase inhibitors were being developed in major pharmaceutical companies...