Word: azt
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...something the Lancet study did not consider. In the new study, published on Thursday, a team of scientists from the University of California, the University of Tennessee and the University of Ottawa analyzed data from San Francisco, where antiretroviral drugs have been extensively prescribed to HIV patients since AZT was introduced in 1987. In that city, drug resistance has grown steadily and, according to the team's models, drug-resistant infections are now on the verge of spiking. (See pictures of Africa's AIDS crisis...
Approved by the Food and Drug Administration in 1997, Combivir was the first pill to combine HIV drugs, and it contained the first-ever agent approved for the treatment of AIDS - zidovudine (better known as AZT) as well as lamivudine (3TC). Both drugs were part of the first class of medications used to fight HIV, and until recently, they formed the backbone of combination therapy against HIV. (See pictures of Nidal Malik Hasan's apartment...
While relatively safe, in recent years the drug's AZT portion has been linked to abnormal loss of fat deposits, particularly in the face and limbs. Other medications that patients only need to take once a day, as opposed to AZT's twice-daily dosing, have also made Combivir less popular in today's AIDS lexicon than it once...
...what HIV was. When Pena was young, her mother told her that the medications she took every day were for ear infections, and, Pena says, "you believe your parents." When she was nine, she finally asked her mother about the drugs and learned the truth. "I had started on AZT at five, and throughout my childhood, I was on various studies of new medicines, like 3TC. I was a complete test case," she says. "I had spinal taps, fluid checks, brain scans, bone density scans; you name it, I've done...
...newest antiretroviral (ARV) drugs. In fact, there weren't any HIV treatments for adults, much less children, in 1986. Saleem, who contracted the virus from her mother, an intravenous-drug user, was 4 when she took her first AIDS drug, and even then the only option she had was AZT. Today doctors know that the best way to fight the virus is to hit it with three drugs at once, one of which is preferably a protease inhibitor. But early patients like Saleem had to learn the hard way. As her virus became resistant to one drug after another, Saleem...