Word: azt
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...studies of HIV-positive pregnant women in developing countries? The New England Journal of Medicine thinks so ? their normally temperate editorial page this week was devoted to a blistering attack on the National Institutes of Health and Centers for Disease Control. The organizations have been giving the AIDS drug AZT to half of the infected mothers in their international study, while the other half get placebos ? and according to the journal, this is as ethically shaky as the notorious Tuskegee study, a 1950s experiment that denied syphillis treatment to black men in Alabama. But as TIME Medical Correspondent Christine Gorman...
...protein, it turns out, bears an intriguing resemblance to an enzyme produced by HIV, the retrovirus that causes AIDS. Indeed, the AIDS drug AZT has already been shown to inhibit telomerase activity. But the viral enzyme and the human enzyme, says Colorado's Cech, are only 20% identical, which explains why AZT is not an ideal telomerase inhibitor. "What we want," he declares, "is a compound that fits telomerase the way a hand fits a glove...
Lurie said that Fawzi's study, based in Tanzania, provided some experimental drug therapy for the infected women but withheld AZT for the duration of the project...
Public Citizen rejects any study that does not provide all subjects with AZT...
Lurie praised Lallemant, who conducted his research in Thailand, for providing all mothers in his project with AZT...