Word: azt
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PEOPLE INFECTED WITH HIV, THE AIDS VIRUS, MAY not show overt symptoms for years. Even so, they are often given AZT, a drug believed to lengthen the lives of those with full-blown AIDS. Several studies have shown that AZT can delay the onset of symptoms, though it doesn't prevent or cure the disease...
...largest and longest-term investigation ever done has come to exactly the opposite conclusion. A three-year Anglo-French study reported in the current issue of the Lancet found that patients infected with HIV follow about the same course into disease and death whether or not they take AZT early on. The finding doesn't question AZT's benefits for those who already have symptoms. And it is being viewed cautiously by AIDS researchers; a single study won't change standard therapeutic practice. It does, however, call into question the prescribing of an expensive drug, and guarantees that the search...
...causes AIDS for 14 years. At 6 ft. 2 in. and 170 lbs., Anderson has only routine medical complaints: the stuffiness of an occasional head cold or the aches and pains of a flu. His good health is not the work of some miracle drug: he has never taken AZT or any other compound to fight HIV. Incredible as it sounds, Anderson's own immune system seems to have held the villainous virus at bay. "It feels good to be on the winning side of HIV," he says. Looking to the future with surprisingly little fear, he hopes...
Drugs such as AZT and ddI offer some temporary firepower against the HIV virus. In February, a medical student at Massachusetts General Hospital in Boston reported that adding a third drug, pyridinone, to the medicinal fusillade obliterates the virus, but that test-tube result remains to be duplicated in humans. Most of the progress has come from the prevention and treatment of the dangerous secondary infections that are the hallmark of AIDS...
...most feared complications of AIDS is its ability to attack the nervous system. Sometimes HIV infects the brain, causing memory loss and other problems. This condition can be treated in children with AZT because the antiviral drug manages to penetrate the cellular barrier that protects the brain. In adults who develop dementia, higher doses are required and may be only partially effective...