Word: azt
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...four years, the list of approved drugs for AIDS patients began and ended with AZT. The drug, also called zidovudine, can extend a patient's life-span, but not everyone can tolerate its side effects, which may include nausea and severe anemia. Now, after billions of dollars of research and constant pressure from AIDS activists, the Food and Drug Administration has bypassed some of its usual requirements to approve another medication, didanosine, known...
...hygiene. Plevy, appalled by the extreme understaffing she encountered in the maximum-security ward of a hospital for the criminally insane, has already taken action to cut red tape on personnel matters. But her report will raise other prickly questions. "Resources are limited," she says. "Should we pay for AZT when you know it will only make that one better for a while, or should we use that money for prevention? Should Medicaid pay to keep comatose patients alive indefinitely? This gets you into really tough choices...
...antibodies whether or not they are actually infected, standard antibody tests are inconclusive. PCR, however, can home in on the minute quantities of viral DNA that may be present in only 1 out of 100,000 . cells. A positive diagnosis means the baby can immediately begin therapy with AZT...
...hopes on the dark horizon of an AIDS patient. Recent studies, including one reported at last month's International Conference on AIDS in Florence, have shown that DDC, formally known as dideoxycytidine, can reduce the activity of the AIDS virus, especially in combination with the medication AZT. Although Hoffman-La Roche has made the drug available to 4,000 participants in a research program, many people remain ineligible because they are on other anti-AIDS drugs or do not yet have symptoms of the disease. But the major obstacle is that the drug has yet to be approved...
...research," says Yale medical school dean Leon Rosenberg. Last year alone, NIH scientists or their associates on university campuses began the first federally sanctioned gene therapy on a human, located the cystic fibrosis gene, developed a drug to reduce paralysis from spinal-cord injuries and demonstrated that the drug AZT prolongs life in AIDS patients...